
Hydroxysafflor yellow A
CAS No. 78281-02-4
Hydroxysafflor yellow A( Hydroxysafflor yellow A | Safflomin A )
Catalog No. M15954 CAS No. 78281-02-4
Hydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities.
Purity : >98% (HPLC)






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5MG | 49 | In Stock |
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10MG | 82 | In Stock |
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25MG | 148 | In Stock |
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50MG | 254 | In Stock |
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Biological Information
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Product NameHydroxysafflor yellow A
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NoteResearch use only, not for human use.
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Brief DescriptionHydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities.
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DescriptionHydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacity and inhibiting the expression of TGF-β. It prevents steroid-induced avascular necrosis of femoral head by inhibiting primary bone marrow-derived mesenchymal stromal cells. Also, Hydroxysafflor yellow A has anti-tumor effects.
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In VitroCell Migration Assay Cell Line:VSMCs Concentration:0.1, 1, 10,100 μM Incubation Time:24 h Result: Inhibited LPS-induced VSMCs proliferation and migration with the concentration of 10 μM.Western Blot Analysis Cell Line:VSMCs Concentration:10 μM Incubation Time:24 h Result:Inhibited LPS-induced upregulation of pro-inflammatory factors (TNF-α, IL-6, and IL-8).Inhibited LPS-induced upregulation of TLR-4 and activation of Rac1/Akt pathway.Cell Viability Assay Cell Line:3T3-L1 Concentration:0.01, 0.1, 1, 10 mg/L Incubation Time:4, 8, 24, 48, 72, 96 h Result:Inhibit the cell viability in a dose and time-dependent manner.Apoptosis Analysis Cell Line:HepG2, Huh7 Concentration:20, 40, 80, 160 μM Incubation Time:24 hResult:Suppressed the growth and induced apoptotic cell death in both concentration and time-dependent manners.
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In VivoAnimal Model:Liver injury model induced by alcoholDosage:2.5 or 10 mg/kg Administration: i.p. daily for 6 weeks Result:Decreased the level of ALT and AST. Decreased the levels of HA, LN, and III-C.Increased the activities of SOD and GPx and decreased the level of TGF-β1 expression.Animal Model:Chronic obstructive pulmonary disease (COPD)Dosage:30, 48, 76.8 mg/kg Administration:i.p.Result:Inhibited the elevated IL-6, IL-1β, TNF-α, ICAM-1 and VCAM-1 mRNA Levels.Inhibited the increased phosphorylation and NF-κB p65 levels.
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SynonymsHydroxysafflor yellow A | Safflomin A
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorTGFβ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number78281-02-4
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Formula Weight612.53338
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Molecular FormulaC27H32O16
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Purity>98% (HPLC)
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SolubilityPyridine, Methanol, Ethanol
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SMILESO=C1C([C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)=C(O)C(O)([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(O)=C1C(/C=C/C4=CC=C(O)C=C4)=O
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Chemical Name3,4,5-trihydroxy-2-((E)-3-(4-hydroxyphenyl)acryloyl)-4-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)cyclohexa-2,5-dien-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhu HJ, et al. Cytotechnology. 2015 Oct;67(5):885-92.
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